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Diagnostics and Surveillance Networks

JPIAMR is launching a transnational network call under the umbrella of the JPIAMR and within the framework of the ERA-NET JPIAMR-ACTION. The call Diagnostics and Surveillance Networks involves funding organisations from 11 countries to date. Networks can be funded with a maximum of 50,000 Euro each.

Call picture Diagnostics and Surveillance Networks 2022. Shadows of people on a colourful background.

This call is closed

The aim of this call is to assemble networks of leading experts and stakeholders with an intent to facilitate the development, optimisation and use of diagnostic and surveillance tools, technologies and systems. Networks should work towards the conceptualisation of ideas in order to provide white papers, guidance documents and/or best practices/roadmaps and evidence frameworks to identify key questions to be addressed and/or potential solutions to overcome barriers to enhanced surveillance and advanced diagnostics to reduce the burden of AMR.

Networks should connect experts from research performing organisations and/or establish clusters with different relevant stakeholders and end users in the AMR community. Networks may build upon new or existing global collaborations/partnerships.

Eleven (11) JPIAMR-ACTION members are participating in this network call. Each network coordinator will be able to apply for a maximum of 50,000 Euro for 12 or 24 months period for support of its activities. The total budget of the call is approximately 1 M Euro.

Please note that JPIAMR network calls do not fund research projects.

Topic of the call

Networks should design and implement ways to support AMR research considering at least one of the two JPIAMR Strategic Research and Innovation Agenda (SRIA) priority topics Diagnostics and Surveillance.

Networks should also aim to address one or more of the following topics:

  1. Identify actions that will improve the diagnostics and surveillance of AMR (in humans and/or animals and/or agriculture and the environment). 
  2. Identify actions needed to support the development of new tools, technologies and systems for diagnosis and surveillance.  
  3. Identify novel or existing data platforms that can be developed or improved to aid international alignment and support the use of surveillance data and/or diagnostics to improve prescription of narrow-spectrum antimicrobials and support alignment with stewardship programmes. 
  4. Identify or assess user needs for tools, technologies, or systems for diagnostics and/or surveillance in appropriate One Health settings.  
  5. Identify the data collection needed to understand inequality in access to diagnostics and how socio-economic factors contribute to this inequality.  
  6. Extend or continue activities of previously funded JPIAMR networks within Surveillance.

Eligibility

Network should consist of a minimum of fifteen (15) partners (including coordinator) from at least ten (10) different countries. In addition, at least three (3) of the partners must come from three (3) different countries whose funding agencies are participating in the call. A network must include at least three (3) early career researchers.

Networks are encouraged to consider gender and geographical diversity among partners.

Information & application

Please contact the call secretariat if you have any questions about the call: jpiamr2022ncs@lmt.lt

Webinar for applicants

A live webinar for applicants was held on the 25th of April 2022 presenting the call and the partner search tool. Representatives from funders participating in the call were available to answer questions.

The webinar was recorded and the videos are now available on the JPIAMR YouTube channel:

Questions and Answers:

Partner search tool

A match-making tool has been created for applicants to facilitate creation of networks. The tool can be used for:

  • Partner looking for the network: an individual searching for a network to join.
  • Network looking for partners: when somebody wants to build a network of experts for the implementation of a particular idea.

Partner search tool for the call Diagnostics and Surveillance Networks

Timeline

12 April 2022 (11.00) – Call opens

25 April 2022 (13.00 CEST) – Webinar for applicants

14 June 2022 (14.00 CEST) – Proposal deadline

Previous JPIAMR network calls

Learn more on the previous JPIAMR network calls:

Funders

Estonia
Estonian Research Council (ETAg)

France
Agence Nationale de la Recherche (ANR)

Italy
Ministero della Salute (It-MoH)

Ireland
Health Research Board (HRB)

Lithuania
Research Council of Lithuania (RCL)

Moldova
Agentia Nationala Pentru Cercetare Si Dezvoltare (ANCD)

Netherlands
Zorgonderzoek Nederland Zon (ZonMw)

Norway
Research Council of Norway (RCN)

Spain
Instituto de Salud Carlos III (ISCIII)

Sweden
Swedish Research Council (SRC)

United Kingdom
Medical Research Council (UKRI/MRC)

Supported projects

Antimicrobial Stewardship in Hospitals, Resistance Selection and Transfer in a One Health Context (STRESST)

The transfer of antibiotic residues and antibiotic resistant bacteria into the environment and subsequently into animal drinking water may have an effect on the transmission of resistant bacteria and their resistance genes back into the human population.

This holistic One Health view of antibiotic resistance is at the heart of our project. We want to determine if hospital wide antimicrobial stewardship implementation will reduce antibiotics and antibiotic resistant bacteria from entering the environment and if the reduction of antibiotic concentrations will lower the transfer of resistance genes within and between bacteria in the environment and in animals. We will show that hospital wastewater is a hotspot for selection of resistance and pave the way for future, targeted interventions aimed at reducing the amounts of antibiotics released into the environment even further.

Project partners

  • Adam Roberts, Liverpool School of Tropical Medicine, United Kingdom (Coordinator)
  • Andrew Singer, UK Centre for Ecology and Hydrology, United Kingdom
  • Nina Langeland, University of Bergen, Norway
  • Michael Brouwer, Wageningen Bioveterinary Research, Netherlands

Call

Strengthening implementation of National Action Plans through a One Health AMR full economic costing exercise (SNAP ONE)

Antibiotic resistance costs lives and money. Yet if we don’t have a good grasp of the numbers we will never know where it lies in terms of our other national priorities.

In Africa we have especially little evidence on how people, animals, and the environment are affected by it. So those who make decisions do not see it at a particular problem and, as a consequence, those who hold the purse strings in government do not fund the necessary efforts to combat antibiotic resistance.

This project will estimate the full economic burden imposed by antibiotic resistance (epidemiological and financial) in Malawi and Zambia in order to fill this evidence gap. Findings from this work should help enhance political will to take greater action. It will also allow more informed decisions to be made about how best to tackle antibiotic resistance locally by calculating the important cost-related numbers that allow different strategies to be compared. Crucially this project will bring together the key people needed to make real and further progress on this issue each of these two countries. And, if successful, Malawi and Zambia will be setting the example for how to combat antibiotic resistance in other parts of Africa.

Project partners

  • Chantal Morel, University Hospital Bonn, Germany (Coordinator)
  • Finola Leonard, University College Dublin, Ireland
  • Chisomo Msefula, University of Malawi, College of Medicine, Malawi
  • Luigia Scudeller, Azienda Ospedaliero-Universitaria di Bologna, Italy
  • Lloyd Matowe, Eden University, Zambia
  • Herman Goosens, University of Antwerp, Belgium

Call

Selecting Efficient Farm-level Antimicrobial Stewardship Interventions from a one health perspective (SEFASI)

Antimicrobial resistance (AMR) links together people, plants, animals and their environments under the One Health umbrella. In this work we will similarly link interventions aimed at AMR by considering their impact not only in terms of impact on hospitals, communities or farmers, but across all of these groups.

This is key to informing optimal intervention selection by governments in tackling AMR in the future. Our research will combine statistical analysis, mathematical simulations and economic-impact models within a single intervention assessment framework. We will bring together an interdisciplinary team of economists, mathematical modellers and veterinary scientists to apply this modelling framework to three country cases studies: England, Senegal and Denmark. All three countries are global leaders in terms of AMR data collection and intervention, providing ideal settings for intervention assessment. Our outcome will be a ranking of farm-level interventions for policymakers to assess their impact from a One Health perspective, and an insight into where more data in the future would be most beneficial, in terms of reducing uncertainty in such economic evaluations of interventions.

Project partners

  • Gwenan Knight, London School of Hygiene and Tropical Medicine, United Kingdom (Coordinator)
  • Michel Dione, International Livestock Research Institute, Senegal
  • Ana Mateus, Royal Veterinary College, United Kingdom
  • Nichola Naylor, Public Health England, United Kingdom
  • Dagim Belay, University of Copenhagen, Denmark

Call

Phage treatment and wetland technology as intervention strategy to prevent dissemination of antibiotic resistance in surface waters (PhageLand)

PhageLand is aimed to develop a novel intervention strategy combining the low-cost and eco-friendly capacity of constructed wetlands with the specificity of bacteriophages (i.e., viruses killing bacteria) to prevent the dissemination of antibiotic resistance from wastewater into surface waters.

PhageLand will investigate the prevalence of antibiotic resistant bacterial pathogens (ARB) in low-middle income countries (LMICs) in Eastern Europe, which will be then used as targets for the development of a dedicated phage-based treatment for their specific removal from communal wastes.

In parallel, PhageLand will assess: a) the purification capacity of two reference, full-scale constructed wetlands operating in Spain and Moldova in the removal of antibiotic residues, ARB and antibiotic resistance genes; and b) the potential risk associated with the dissemination of these biological pollutants within indigenous bacterial communities and among animals inhabiting constructed wetlands.

Finally, PhageLand will develop a pilot plant to scale-up the phage-wetland combined technology to assess its performance under real environmental conditions. This proof-of-concept will be used to demonstrate the efficacy of this nature-based technology for the removal of multidrug-resistant pathogens from communal wastes and to encourage stakeholders for its implementation in wastewater treatment to prevent the dissemination of antimicrobial resistance. The PhageLand technology will be particularly useful in LMICs, where costly and power-demanding treatment plants are difficult to set up.

Project partners

  • Carles Borrego, Catalan Institute for Water Research, Spain (Coordinator)
  • Lukasz Dziewit, University of Warsaw, Poland
  • Malgorzata Grzesiuk-Bieniek, Warsaw University of Life Sciences, Poland
  • Rob Lavigne, KU Leuven, Belgium
  • Evelien Adriaenssens, Quadram Institute Bioscience, United Kingdom
  • David Weissbrodt, Delft University of Technology, Netherlands
  • Alina Ferdohleb, Nicolae Testemitanu State University of Medicine and Pharmacy, Moldova

Call

Interventions to decrease CRE colonization and transmission between hospitals, households, communities and domesticated animals (I-CRECT)

In middle-income countries antibiotic resistance is increasing causing suffering and high mortality. In 12 Vietnamese hospitals half of patients were colonised with “superbugs” called carbapenem resistant Enterobacteriaceae, for short CRE , at admission 13% and after 2 weeks in hospital 89%.

CRE colonization cause hospital infections and high mortality. As many patients are CRE colonized at hospital discharge it can spread to the household members and out in community and environment. If CRE spreads in the community it will be very difficult to treat community infections as urinary tract infections and pneumonia, increasing treatment times, costs and mortality. It is hence important to stop the spread of CRE from hospitals to community.

In our research we will follow patients that are CRE colonised at discharge out to their households. The households will be randomized to intervention and control group. An intervention to improve hygiene and decrease unnecessary antibiotic use will be evaluated on CRE transmission in the household and to domesticated. Colistin, a last resort antibiotic for very ill patients, is often used for animals in feed as growth promoter, selecting for antibiotic resistance that boomerang back into hospitals. We will assess colistin resistance in households and animals and to targeted interventions to reduce transmission. Wastewater from hospitals will be tested for antibiotics and resistant bacteria. To check the relatedness of bacteria in humans, animals and environment resistance genes will be investigated.

Project partners

  • Håkan Hanberger, Linköping University, Sweden (Coordinator)
  • Phuc Duc Pham, Hanoi University of Public Health, Vietnam
  • Dien Minh Tran, Vietnam National Children’s Hospital/ Research Institute of Childrens Health, Vietnam
  • Yaovi Mahuton Gildas Hounmanou, University of Copenhagen, Denmark
  • Mattias Larsson, Karolinska Institutet, Sweden
  • P Velavan Thirumalaisamy, The Universitätsklinikum Tübingen, Germany
  • Flavie Goutard, Centre de coopération internationale en recherche agronomique pour le développement, France

Call

Microbiota Intervention Strategies Limiting Selection and Transmission of Antibiotic Resistance burden in the One Health domain (MISTAR)

The central aim of MISTAR is to implement and quantify the effect of novel intervention strategies based on the preservation of the “healthy microbiota” to eradicate and control the spread of antimicrobial resistance (AMR).

We will do this using a One Health approach that involves hospitalized patients, healthy humans, pets, farm animals and the environment. In MISTAR we will follow three main approaches to control the spread of AMR. (i) Intervene with the gut microbiota either by prioritizing potential interventions based of microbiota composition indices/diagnostic tools or by using fecal microbiota transplantation (FMT) to modulate the gut microbiota to reduce and possibly avoid the colonization of and further infections by multidrug resistance pathogens. (ii) Intervene with airborne dust-bound spread of antibiotic resistant bacteria (ARB) between pets and humans in households, farm animals and hospitalized patients by applying air purifiers to remove these microorganisms from the air. Finally, we will (iii) develop novel innovative intervention approaches aimed at specifically targeting ARB in complex microbial communities, like the intestinal tract and sewage.

MISTAR will bring perspectives on novel interventions to reduce the emergence of antibiotic resistance that can readily be integrated into existing organisational structures that are also applicable in low-and-middle income countries, and innovative technologies, which needs investment.

Project partners

  • Marcel de Zoete, University Medical Centre Utrecht, Netherlands (Coordinator)
  • Teresa M. Coque, Instituto Ramón y Cajal de Investigación Sanitaria, Spain
  • Surbhi Malhotra- Kumar, University of Antwerp, Belgium
  • Stineke van Houte, University of Exeter, United Kingdom
  • Willem van Schaik, University of Birmingham, United Kingdom
  • Alex Bossers, Utrecht University, Netherlands
  • Ilana Lopes Baratella da Cunha Camargo, University of São Paulo, Brazil

Call

Targeted removal of ARGs and facultative pathogenic bacteria (FPB) in wastewater from AMR hotspots using modular advanced treatment solutions (HOTMATS)

The objective of the project HOTMATS is to design and demonstrate effective and compact solutions for the source-treatment of wastewater emitted from AMR hotspots.

The goal is to stop the spreading of antimicrobial resistant bacteria (ARB), antibiotic resistance genes (ARG), and other health-critical microorganisms from hotspots to the public sewage network, which currently is one of the major AMR transmission links between the three pillars of One-Health. This intervention will unburden the sewage network including wastewater treatment plants from the load of AMR, and hence reduces their release to the environment.

The capability of different treatment principles will be investigated, novel treatment units will be designed, and the destruction of ARB/ARGs in contaminated wastewater will be demonstrated. Ozone, AOP, MF, and UV-C based pilot-reactors will be developed and their effectiveness to destroy ARB/ARGs in concentrated wastewater streams will be assessed at a hospital, nursery homes, and animal facilities.

Compared to existing methods, the investigated treatment solutions are more effective, have a lower footprint, and consume less energy and resources, making them attractive options for treatment at AMR hotspots, as retrofits at old building infrastructures, and where space is limited. The socio-economy assessment including the transfer from HIC to LMIC is part of the HOTMATS project by integration partners from LMICs.

Project partners

  • Thomas Schwartz, Karlsruhe Institute of Technology, Germany (Coordinator)
  • Carsten Schwermer, Norwegian Institute for Water Research, Norway
  • Jaqphet Opintan, University of Ghana, Ghana
  • Richard Wulwa, University of Nairobi, Kenya

Call

Ionophore coccidiostats: risk of CO-selectioN of antImicrobial resistance – Clinical impact and intervention strategies (ICONIC)

Today’s intensive broiler production is highly dependent on in-feed ionophore coccidiostats. Because these ionophores are not used in humans, it is widely assumed that their use in poultry is not a risk for human health.

Recent evidence, however, suggests that they may cause co-selection of medically important antimicrobial resistance. This means that the use of ionophores can cause the spread of bacteria which, when they cause infections in humans, cannot be treated with certain antibiotics.

The ICONIC project aims to gain more insight into the magnitude of this problem by a analyzing and comparing bacteria from poultry, environment and humans. The results will yield a better understanding of the human health impact of ionophore use in poultry industry. In parallel, the project will investigate the effects of alternatives to the use of ionophores, providing leads for reducing the risk of resistant bacteria transmitting from the poultry chain to humans.

Project partners

  • Mariel Pikkemaat, Stichting Wageningen Research, Netherlands (Coordinator)
  • Anne Margrete Urdahl, Norwegian Veterinary Institute, Norway
  • Roger Simm, University of Oslo, Norway
  • Daniela Maria Cirillo, San Raffaele Scientific Institute, Italy
  • Isabelle Kempf, Anses, laboratoire de Ploufragan, France
  • Jowita Niczyporuk, National Veterinary Research Institute PIWet, Poland

Call

Designing One Health Governance for Antimicrobial Stewardship Interventions (DESIGN)

AMR is a problem of the global commons, whose resolution depends on coordination of collective global strategy. Addressing the challenges posed by AMR through a One Health approach relies on inter-sectoral policy coordination – across public health, agricultural, and environmental sectors – internationally, making stewardship complex, necessitating new approaches to policy development.

Our research seeks to address these issues through a comparative analysis that will identify innovative international policy, legal and regulatory approaches in high-, medium- and low-income case study countries. We will apply systems analysis to understand the complex contingencies inherent in local and international contexts in order to clarify the manner in which national systems could better support the coordinated efforts of public health, agricultural, environmental sectors, professional groups, public and private sectors, and civil society to secure their cooperation.

Design thinking workshops will leverage evidence emerging from the systems analysis by engaging governments and local stakeholders. Workshops will identify the incentives that foster a One Health approach to the governance of AB stewardship, including innovative governance approaches that support the development of regional and national policies, regulations and laws to improve the global commons. The findings will be used to advise government, industry, public health and environmental agencies on solutions that foster implementation of a One Health approach to reduce AMR.

Project partners

  • Mary E. Wiktorowicz, York University, Canada (Coordinator)
  • John Paget, Netherlands Institute for Health Care Research, Netherlands
  • Marion Bordier, Agricultural Research for Development, France
  • Alpha Amadou Diallo, Institut Sénégalais de Recherches Agricoles, Senegal
  • Marilen Balolong, University of the Philippines, Philippines
  • Ria Benko, University of Szeged, Hungary

Call