In order to protect and prolong the usefulness of existing antimicrobials, increasing cross-sectoral efforts are needed to rationalize their use and misuse in human and animal health and food production settings.
Key measures to achieve this are to improve existing and implement new evidence-based control, prevention, stewardship and intervention strategies to reduce the risk of acquisition, development and transmission of antibiotic-resistant bacteria and infection caused by these pathogens, in hospitalized patients, outpatients, healthy people, animals and the environment.
Despite significant investments in research and increased knowledge about the development, acquisition, occurrence, and transmission pathways of AMR, little of this research has translated into interventions to significantly improve health care by reducing improper antibiotic usage or infections by resistant microbes.
In summary, controlled integrated studies between human population, health care systems, and agricultural settings, multiple sectors are urgently needed to devise the optimal intervention strategies across diverse cultural settings and heterogeneous systems of human health and animal health and food production.
It is expected that through international collaborations that combine complementary and synergistic research strengths, this JPIAMR call will increase the understanding of prevention, control, stewardship and intervention strategies for AMR infections. Proposals are expected to clearly define targets and milestones to deliver relevant outcomes within the funding period.
The call will cover research addressing the following topics:
- One Health oriented pilot studies to determine feasibility and protocols for future large scale multi-center and multi-national studies of different prevention or intervention strategies designed to prevent AMR infections in community, health care, agricultural and environmental settings. The One Health approach is encouraged, but not mandatory.
- Compared effectiveness and economic evaluation of the implementation of new and/or more cost-effective methods for rapid detection and diagnosis of infections by multi-drug resistant microorganisms (MDR) for the purpose of identification of appropriate therapy, transmission routes or early detection of outbreaks in different settings.
- Investigations of efficacy and effectiveness of behavioral intervention strategies, public awareness strategies or other stewardship strategies aiming at reducing the use and misuse of antibiotics and the development and transfer of AMR.
- Assessment of new methods to improve and raise hygiene and sanitation standards to reduce infections in health and care settings.
- Evaluation of the impact of new ways to standardize and utilize antimicrobial use and transmission data on intervention strategies and prevention of antimicrobial resistance.
Information & application
This call is closed.
The Research Foundation – Flanders (FWO)
Canadian Institute of Health Research (CIHR)
Ministry of Education, Youth and Sports (MEYS)
The Federal Ministry of Education and Research (BMBF)
Deutsches Zentrum für Luft- und Raumfahrt (DLR)
Health Research Board (HRB)
Chief Scientist Office, Ministry of Health (CSO-MOH)
Ministry of Health (IT-MOH)
Valsts izglītības attīstības aģentūra (VIAA)
Zorgonderzoek Nederland (ZON)
The Research Council of Norway (RCN)
Narodowe Centrum Nauki (NCN)
National Authority for Scientific Research and Innovation (ANCSI)
Instituto de Salud Carlos III (ISCIII)
Swedish Research Council (SRC)
Swiss National Science Foundation (SNSF)
Ten projects were awarded funding within the JPIAMR 5th transnational call: “Prevention and Intervention Strategies to control AMR infections”. The total funding amount was 11.5 M€. Click on the project titles in the list below to learn more about each project.
- An Online Platform for Expanding Antibiotic Stewardship (OPEN Stewardship)
- Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens (PILGRIM)
- Piloting on-site interventions for reducing antimicrobial use in livestock farming emerging economies (REDUCE AMU)
- Improving rational prescribing for UTI in frail elderly (ImpresU)
- Antimicrobial Resistance Manure Intervention Strategies (ARMIS)
- A digital antimicrobial stewardship smartphone application to combat AMR: the AB-assistant (AB-assistant)
- Comparative assessment of social-ecological resilience and transformability to limit AMR in one health systems (AMResilience)
- Intervention of antimicrobial resistance transfer into the food chain (INART)
- Aligning industry incentives with AMR control goals: Exploring the feasibility of an antibiotic susceptibility bonus for drugs to treat Gram-negative infection (ASB)
- Preventing transmission of MRSA from livestock to humans through competitive exclusion (ExcludeMRSA)