This section includes collection of resources for early drug discovery, antibiotic pipeline, alternatives to antibiotics including links to chemical libraries, surveillance datasets and antibiotic stewardship guidelines to uncover hidden insights and unlock value of these siloed data sets.
| AMR data platform | Short description | Focus |
|---|---|---|
| AACTING | Network on quantification of veterinary Antimicrobial usage at herd level and Analysis, CommunicaTion and benchmarkING to improve responsible usage (ACCTING) provides overview of fram-level AMU monitoring systems per country and practical guidelines that are intended to provide useful support when designing or revising farm-level AMU monitoring systems to guide antimicrobial stewardship. The aim is to provide a basis for collection of harmonised farm-level data within and among countries. | Antimicrobial stewardship |
| AMRFinderPlus (NCBI) | NCBI has developed AMRFinderPlus, a tool that identifies AMR genes, resistance-associated point mutations, and select other classes of genes using protein annotations and/or assembled nucleotide sequence. | Antimicrobial Resistant Organisms Library |
| AntibioticDB | AntibioticDB is a open-access database of antibacterial compounds that indicates the stage of development of each agent, including discontinued agents, drugs under pre-clinical development, those in clinical trials. This database includes over 1000 compounds which are currently in pre-clinical development, in phases 1-3 of clinical trials, in phase 4 of clinical development either awaiting approval, or recently approved or if the compound has been discontinued. This dfatabase intends to serve as reference or as starting points for future research and re-development. | Antibiotic discovery and development |
| Antimicrobial Encyclopedia | A resource section that define many terms across the antimicrobial R&D field. | Antimicrobial R&D Encyclopedia |
| antiSMASH | antiSMASH (analysis of secondary metabolic biosynthetic gene clusters) allows the rapid genome-wide identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genomes. It integrates and cross-links with a large number of in silico secondary metabolite analysis tools that have been published earlier. | Antibiotic discovery and development |
| ARTS 2.0 | Antibiotic Resistant Target Seeker (ARTS 2.0) is a tool to automate the process of performing target direct genome mining, search for potential novel antibiotic targets, and prioritize putative secondary metabolite gene clusters. The tool provides the opportunity to explore secondary metabolite gene clusters and uncover new resistant targets; screen secondary metabolite gene clusters for known targets; find unique metabolism and resistance factors in SM gene clusters that might lead to the discovery of novel antibiotic targets. | Antibiotic discovery and development |
| ATLAS | Antimicrobial Testing Leadership And Surveillance (ATLAS), is a comprehensive resource that includes a fully-searchable database built initially with antibacterial surveillance data from the TEST (Tigecycline Evaluation Surveillance Trial) surveillance program, followed by data from the AWARE (Assessing Worldwide Antimicrobial Resistance Evaluation) and INFORM (International Network for Optimal Resistance Monitoring) programs. ATLAS now also encompasses data from the SENTRY antifungal surveillance program. | Surveillance database |
| CARD | The Comprehensive Antibiotic Resistance Database (CARD) is a bioinformatic database of resistance genes, their products and associated phenotypes. It includes sequence variants beyond those reported in the scientific literature, as well as prevalence statistics for AMR genes among pathogens, genomes, and plasmids. | Antimicrobial Resistant Organisms Library |
| CO-ADD | The database Community for Open Antimicrobial Drug Discovery (CO-ADD) contains chemical structures and antimicrobial activity data to help screen compound for antimicrobial activity for academic research groups and generate a public knowledge database for the development of novel agents for the treatment of microbial infections. | Antimicrobial compound screening library |
| COlleCtion of Open NatUral producTs (COCONUT) | Natural Products Online is an open source project for Natural Products (NPs) storage, search and analysis. The present version hosts COCONUT, the COlleCtion of Open Natural ProdUcTs, one of the biggest and best annotated resources for NPs available free of charge and without any restriction. | Natural products chemical library |
| Dictionary of Natural Products | The Dictionary of Natural Products (DNP) is a comprehensive and fully-edited database on natural products providing information on chemical substances. It includes descriptive and numerical data on chemical, physical and biological properties of compounds; systematic and common names of compounds; literature references; structure diagrams and their associated connection tables. | Natural products chemical library |
| EML AWaRe | The AWaRe portal is a free online resource intended to increase public awareness of issues regarding antibacterial resistance. It provides detailed information on Access, Watch and Reserve (AWaRe) antibiotics based on the WHO EML classification. It also strives to disseminate EML guidance on optimal antibiotic prescribing among health professionals worldwide detailing 1st and 2nd choice antibiotics listed as essential medicines for most common infectious syndromes. | WHO antibiotic categorisation and stewardship |
| EPI-Net | The Epidemiology Network (EPI-Net) provides access to data on emergence and spread of antimicrobial resistance (AMR) in humans and animals and healthcare-associated infections (HAI). | Surveillance database |
| EUCAST | European Committee on Antimicrobial Susceptibility Testing (EUCAST) deals with breakpoints and technical aspects of phenotypic in vitro antimicrobial susceptibility testing and functions as the breakpoint committee of EMA and ECDC. | Antimicrobial susceptibility testing |
| EU-Openscreen ERIC | EU-Openscreen offers access to high-throughput screening facilities and medicinal chemistry groups for hit optimisation. It provides the basis for computational data integration and allows for prediction of drug-target interactions and networks, adverse effects and drug combinations. | Chemical Biology database |
| JAC-AMR | Antimicrobial resistance and stewardship e-Learning Repository provides a rich blend of peer and non-peer reviewed multi-media antimicrobial resistance and stewardship educational resources from differing health economies across the globe. The resources are classified according to the World Health Organisation national action plan classification system and are searchable using various filters. | Antimicrobial stewardship e-Learning Repository |
| MIBiG | The Minimum Information about a Biosynthetic Gene cluster (MIBiG) specification provides a robust community standard for annotations and metadata on biosynthetic gene clusters and their molecular products. MIBiG will facilitate the standardized deposition and retrieval of biosynthetic gene cluster data as well as the development of comprehensive comparative analysis tools. It will empower next-generation research on the biosynthesis, chemistry and ecology of broad classes of societally relevant bioactive secondary metabolites, guided by robust experimental evidence and rich metadata components. | Chemical Biology database |
| MicroBIGG-E | NCBI has developed the Pathogen Detection Microbial Browser for Identification of Genetic and Genomic Elements (MicroBIGG-E). | Antimicrobial Resistant Organisms Library |
| NaPDos | Natural Product Domain Seeker (NaPDos) is a bioinformatic tool for the rapid detection and analysis of secondary metabolite genes. This tool is designed to detect and extract C- and KS- domains from DNA or amino acid sequence data, including PCR amplicon products, individual genes, whole genomes, and metagenomic data sets. | Natural products chemical library |
| NCBI Isolates Browser | NCBI has developed the Isolates Browser to allow researchers to identify bacterial genomes with AMR genes. | Antimicrobial Resistant Organisms Library |
| NCBI Pathogen Detection Gene Catalog | NCBI Pathogen Detection identifies the antimicrobial resistance, stress response, and virulence genes found in bacterial genomic sequences. NCBI Pathogen Detection integrates bacterial pathogen genomic sequences originating in food, environmental sources, and patients. It quickly clusters and identifies related sequences to uncover potential food contamination sources, helping public health scientists investigate foodborne disease outbreaks. | Antimicrobial Resistant Organisms Library |
| NDARO | National Database of Antibiotic Resistant Organisms (NDARO) is a centralized hub for researchers to access AMR data to facilitate real-time surveillance of pathogenic organisms. It maintains a curated database of AMR genes and collection of genetic and antibiotic susceptibility data. | Antimicrobial Resistant Organisms Library |
| NIH/NIAID (anti-TB drugs) | The ChemDB HIV, Opportunistic Infection and Tuberculosis Therapeutics Database is a tool developed by NIAID to compile and annotate preclinical data on compounds with potential therapeutic action against HIV/AIDS and related opportunistic infections, including Tuberculosis. Entries in the database are organized according to chemical properties and biological activity. | Antibiotic discovery and development |
| PATRIC | The Pathosystems Resource Integration Center (PATRIC) provides integrated data and analysis tools to support biomedical research on bacterial infectious diseases. | Bacterial Bioinformatics Resource Center |
| PEW TRUSTS | The interactive resource from PEW TRUSTS—based on publicly available information and informed by external experts and company communication—focuses on the nontraditional products currently in the clinical development pipeline. | Nontraditional products in the clinical development pipeline |
| PEW TRUSTS | The interactive resource PEW TRUSTS focuses exclusively on small molecule products that act systemically (drugs that work throughout the body), contain at least one component not previously approved, and have the potential to treat serious or life-threatening infections. | Antibiotics in Clinical Development |
| ResistanceMap | ResistanceMap is a web-based collection of data visualization tools that allows interactive exploration of antimicrobial resistance (AMR) and antibiotic use trends in countries across the globe, now including several low- and middle-income countries (LMICs). | Surveillance database |
| SPARK | The Shared Platform for Antibiotic Research and Knowledge (SPARK) is a cloud-based, virtual laboratory that enables scientists to share data and insights, learn from past research, and generate new insights into how molecules enter and stay inside of Gram-negative bacteria. SPARK integrates chemical and biological data from published studies as well as previously unpublished data, and provides an opportunity for real-time collaboration among scientists in industry, academia, government, and the nonprofit sector. | Antibiotic discovery and development |
| Super Natural II | Super Natural II is a database of natural products. It contains 325,508 natural compounds (NCs), including information about the corresponding 2d structures, physicochemical properties, predicted toxicity class and potential vendors. | Natural products chemical library |
| The Surveillance Atlas of Infectious Diseases | The Surveillance Atlas of Infectious Diseases displays data on antimicrobial resistance in different bacterial species collected by the European Antimicrobial Resistance Surveillance Network (EARS-Net) collating data from the Member States collected through the European Surveillance System - TESSy. | Surveillance database |
| VetCAST | Veterinary Committee on Antimicrobial Susceptibility Testing (VetCAST) deals with all aspects of antimicrobial susceptibility testing of bacterial pathogens of animal origin and animal bacteria with zoonotic potential. | Antimicrobial susceptibility testing |
| WAHIS | The World Animal Health Information Database (WAHIS) Interface provides access to all data held within OIE on immediate notifications and follow-up reports submitted by Country / Territory Members notifying exceptional epidemiological events current in their territory; reports stating the health status of OIE-listed diseases in each Country / Territory and reports providing health information and information on the veterinary staff, laboratories and vaccines, etc. | Surveillance database |
| WHO antibacterial clinical pipeline | WHO antibacterial products in clinical development for priority pathogens (antibiotics and biologicals) that were in phase I-III of clinical development (as of September 2019) and which had not, at that date, received market authorization for human use anywhere in the world are listed here. Candidate products are reported by type, pathogen category, phase of clinical development, and expected activity against priority pathogens. There is also an assessment of their innovativeness and whether a new chemical entity is involved. The route of administration, antibiotic class and developers are also reported. | Antibacterial clinical pipeline |
| WHO antibacterial preclinical pipeline | WHO’s first global review of antibacterial products in preclinical development captures 252 antibacterial products that are being developed in 145 institutions around the world. Candidate products are reported by country of development, preclinical stage, treatment modality, infection stage being targeted, product type, mode of action, and pathogen category for pathogen-specific products. Details of bacterial spectrum target, route of administration and developers are also reported. | Antibacterial preclinical pipeline |
| ZINC | ZINC is a free database of commercially-available compounds for virtual screening. ZINC contains over 230 million purchasable compounds in ready-to-dock, 3D formats. ZINC also contains over 750 million purchasable compounds you can search for analogs in under a minute. | Chemical Biology database |
| AMR Insights Technology Database | This overview page provides the easiest to search, growing global overview of Technologies, Products and Services to curb AMR. The Database and Technology Pages are fantastic tools to enable global partnering and matchmaking programs in the AMR space: academic-academic, academic – SME and more. | Technologies, products and services |
