Joint Programming Initiative on Antimicrobial Resistance

TRANSLOCATION-transfer

Network coordinator: Mathias Winterhalter, Jacobs University Bremen, Germany






Summary of the Network

In response to the pharmaceutical industry stepping back from antibiotic discovery, multiple public efforts, including the JPIAMR and IMI ND4BB, as well as the efforts of Biomedical Science (BMS) European Research Infrastructures community have stepped in to fill the gap. In this project, we will set up a knowledge sharing Network, Translocation-transfer (TT) bringing together experts from two major publicly funded programs, with the goal to improve the process of academically driven antibiotic drug discovery by capitalising on recently gained insights into a key bottleneck in anti-bacterial research, namely how compound penetration properties determine efficacy and resistance properties. Three existing communities who will form the TT Network are:

  1. the partners associated with the multinational program Translocation (www.translocation.eu), part of IMI ND4BB;
  2. partner sites from EU-OPENSCREEN, the European Research Infrastructure for chemical biology and screening (www.eu-openscreen.eu) and
  3. partners from the wider global community working on AMR issues and research.

Translocation (1/2013-6/2018) was one of the largest antibiotic research programs in the world specifically devoted to understanding and to devising ways of increasing antibiotic penetration into bacteria. EU-OPENSCREEN began operation in April 2018 and from 2019 onwards will run some 50 chemical biology and academic drug discovery projects per year, across a Network of 25 screening sites, based in eight European countries on behalf of users from across Europe. It is anticipated that at least 20% of EU-OPENSCREEN projects will involve antibiotic drug discovery element.

The initial goal of the TT Network will be to transfer knowledge between Translocation and EU-OPENSCREEN to fully incorporate compound permeation and efflux considerations into academic antibiotic drug discovery. We have the active participation of the Pew Charitable Trust, which will contribute to the long-term systematic dissemination of findings from the co-funded funded Translocation project.

Network composition

Expected outputs of the Network

  • Kick off meeting
  • Map drug discovery efforts on poor permeability characteristics
  • Linkage with existing datasets and develop new dataset
  • Training resources
  • Shared working environment
  • Knowledge sharing plan
  • Final grant report

Matrix

JPIAMR priority topics: Therapeutics, Diagnostics, Surveillance