TRANSLOCATION-transfer
Therapeutics
- Mathias Winterhalter, Jacobs University Bremen, Germany (Coordinator)
- Derek S. Tan, Memorial Sloan Kettering Cancer Center, USA (Observer)
- Olga Genilloud, Fundación MEDINA, Spain (Observer)
- Nevine Sobhy Fam, Theodor Bilharz Research Institute, Egypt (Observer)
- Haim Barr, The Weizmann Institute of Science, Israel (Observer)
- Wolfgang Fecke, EU-OPENSCREEN ERIC, Germany (Observer)
- Jacek Lukasz Kolanowski, Institute of Bioorganic Chemistry, Polish Academy of Sciences (IBCH PAS), Poland (Observer)
- Jean-Marie Pagès, INSERM, French National Institute of Health and Medical Research, France (Observer)
- Ruth Brenk, University of Bergen, Norway (Observer)
- Thilo Köhler, University Hospitals Geneva, Switzerland (Observer)
- Aigars Jirgensons, Latvian Institute of Organic Synthesis, Latvia (Observer)
- Philip Gribbon, Fraunhofer Institute for Molecular Biology and Applied Ecology, IME, Germany (Observer)
- Esin Aki-Yalcin, Ankara University, Turkey (Observer)
- Petr Džubák, Palacky University Olomouc, Czech Republic (Observer)
- Päivi Tammela, University of Helsinki, Finland (Observer)
- Wes Kim, The Pew Charitable Trusts, USA (Observer)
- Paolo Ruggerone, University of Cagliari, Italy (Observer)
- Miguel Viñas, University of Barcelona, Spain (Observer)
- Isabelle Schalk, Biotechnologie et Signalisation Cellulaire, France (Observer)
- Francoise Van Bambeke, Katholieke Universiteit Leuven, Belgium (Observer)
- Helen I. Zgurskaya, University of Oklahoma, USA (Observer)
- Emad Tajkhorshid, Beckman Institute for Advanced Science and Technology, USA (Observer)
Translocation-transfer aims to improve academically driven antibiotic drug discovery on a key bottleneck in anti-bacterial research, namely how compound penetration determine efficacy and resistance properties. There is an urgent need for discovery and development of new drugs to combat multi-resistant organisms. The search for new drugs is cumbersome, particularly because the current business model for antibiotics in the pharmaceutical industry has stalled because of the poor return on investment. In response to the pharmaceutical industry stepping back from antibiotic discovery, multiple public efforts, including the JPIAMR and IMI ND4BB, as well as the efforts of Biomedical Science (BMS) European Research Infrastructures community have stepped in to fill the gap. Translocation-transfer (TT) brings together experts from with two major publically funded programs, with the goal to improve the process of academically driven antibiotic drug discovery by capitalising on recently gained insights into a key bottleneck in anti-bacterial research, namely how compound penetration properties determine efficacy and resistance properties. Three main communities form the TT network: i) the partners associated with the multinational program Translocation (www.translocation.eu), part of IMI ND4BB; ii) partner sites from EU-OPENSCREEN, the European Research Infrastructure for chemical biology and screening (www.eu-openscreen.eu) and iii) partners from the wider global community working on AMR issues and research.
- Microorganisms, 2020. When Combined with Colistin, an Otherwise Ineffective Rifampicin–Linezolid Combination Becomes Active in Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii
- Expert Opinion on Drug Delivery, 2020. Antibiotic uptake through porins located in the outer membrane of Gram-negative bacteria
- Expert Opinion on Drug Discovery, 2021. Future prospects for Antimicrobial peptide development: peptidomimetics and antimicrobial combinations.