A relatively recent advance in microbiology is the finding that the majority of infections are caused by bacterial biofilms.
Biofilms are structured communities of bacteria found on surfaces that become embedded within a self-produced extracellular polymeric matrix. Biofilms can form on tissues or on biomedical surfaces, such as blood catheters or implants, where they act as a reservoir of potential healthcare associated infection. Bacteria living in biofilms can tolerate much higher antibiotic concentrations compared to planktonic bacteria and survive long enough to evolve antimicrobial resistance (AMR). They form persistent, hard to treat infections and exhibit an intrinsic biology that promotes the development and transmission of AMR.
The goal of our consortium is to determine how bacteria adapt to antimicrobials during biofilm formation on surfaces coated with antimicrobials, how AMR mutations are acquired and evolve within mature biofilms, and how population dynamics within biofilms affect the transmission of AMR. We address the hypothesis that understanding the contribution of biofilms to AMR acquisition and spread will lead to the development of novel antimicrobial strategies and medical devices that are more effective in preventing biofilm-associated infection and AMR.
Our team provides facilities and clinical research governance for experimental and translational medicine. Our synergy of leading laboratory, clinical and translational research across Europe will ensure the best chance to develop novel and successful interventions and therapeutic outcomes.
- Frank Schreiber, BAM-Federal Institute for Materials Research and Testing, Germany (Coordinator)
- Qun Zulian Ren, Empa. Materials Science and Technology, Switzerland
- Henny C van der Mei, University Medical Center Groningen, Netherlands
- Saul Faust, University Hospital Southampton, United Kingdom
- Matthias Buhmann, Empa. Materials Science and Technology, Switzerland
- Henk J. Busscher, University Medical Center Groningen, Netherlands
- Jeremy Webb, University of Southampton, United Kingdom
- bioRxiv, 2020. An integrated model system to gain mechanistic insights into biofilm formation and antimicrobial resistance development in Pseudomonas aeruginosa MPAO1
- Journal of Hospital Infection, 2020. Selection of resistance by antimicrobial coatings in the healthcare setting
- npj Biofilms and Microbiomes, 2020. An integrated model system to gain mechanistic insights into biofilm-associated antimicrobial resistance in Pseudomonas aeruginosa MPAO1