Risk of companion animal to human transmission of antimicrobial resistance during different types of animal infection (PET-Risk )
Infections in humans due to antimicrobial resistant bacteria originating from pets are becoming a concern. While any animalhuman contact offers a chance of transmission, it is generally accepted that a high bacterial burden and high antimicrobial resistance gene copy numbers are present during an active infection. There is a gap of knowledge on the dynamics of transmission and selection of antimicrobial resistance at the pethuman interface. Animals may exchange antimicrobial-resistant bacteria and resistance genes with humans, but the extent to which this happens is unknown.
PET-Risk will evaluate the transfer of antimicrobial resistance between pets and household members during animal infections and determine which type of infection (skin and soft tissue vs. urinary tract infections) presents a higher risk of transmission to humans. Furthermore, in a longitudinal study we will collect samples of infected animals under antimicrobial treatment, and their household members at several time points, which will allow the assessment of critical control points at which interventions could substantially affect the spread of resistance. The causality and directionality of pet-human spread of resistance genes will be established by using state-of-the-art techniques in order to design and evaluate preventive and intervening measures for reducing the public health risks of antimicrobial resistance.
- Constança Ferreira Pomba, University of Lisbon, Portugal (Coordinator)
- Stefan Schwarz, Friedrich-Loeffler-Institut, Germany
- Scott Weese, Ontario Veterinary College at the University of Guelph, Canada
- Anette Loeffler, The Royal Veterinary College, United Kingdom
- Vincent Perreten, University of Bern, Switzerland
The close contact of companion animals with humans provides excellent opportunities for interspecies transmission of resistant bacteria and their resistance genes in either direction. There is a gap of knowledge on the dynamics of transmission and selection of antimicrobial resistance at the companion animal-human interface.
Pet-Risk is evaluating the transfer of antimicrobial resistance between companion animals and household members during animal active infections and determine which type of infection (skin and soft tissue vs urinary tract infections) promotes a higher risk of transmission of antimicrobial resistance to humans. We already know that sick animals in contact with humans tend to favour colonization by resistant bacteria in both species. The first report of a OXA-181 E. coli producer in a dog from Portugal and the sharing of ESBL-producing Enterobacteriaceae between humans and pets are already under scrutiny.
Furthermore, preliminary results by rep-PCR seem to point to the detection of some families sharing ESBL-producing Enterobacteriaceae between humans and pets. The causality and directionality of spread of resistance genes between humans and companion animals will be established in order to design and evaluate preventive and intervening measures for controlling resistance and diminishing the public health consequences of antimicrobial resistance.
- Journal of Veterinary Internal Medicine, 2020. Extended‐spectrum‐beta‐lactamases‐ and carbapenemase‐producing Enterobacteriaceae isolated from the gut of sick companion animals in Portugal
- Journal of Veterinary Internal Medicine, 2020. Plasmid‐mediated colistin resistance mcr‐1 gene harbored on multi‐drug resistant isolates from companion animals in Portugal
- Chapter in Advances in Animal Health, Medicine and Production, 2020. The Public Health Risk of Companion Animal to Human Transmission of Antimicrobial Resistance During Different Types of Animal Infection
- Chapter in Advances in Animal Health, Medicine and Production, 2020. The Gut Microbiome and Antimicrobial Resistance in Companion Animals
- Chapter in Advances in Animal Health, Medicine and Production, 2020. Antimicrobial Resistance Trends in Dogs and Cats with Urinary Tract Infection
- Microbial Drug Resistance, 2020. Sharing of Clinically Important Antimicrobial Resistance Genes by Companion Animals and Their Human Household Members
- Microorganisms, 2020. Genes on the Move: In Vitro Transduction of Antimicrobial Resistance Genes between Human and Canine Staphylococcal Pathogens
- Veterinary Microbiology, 2019. Clonal relatedness of Proteus mirabilis strains causing urinary tract infections in companion animals and humans
- Journal of Antimicrobial Chemotherapy, 2019. Emergence of Escherichia coli ST131 H30/H30-Rx subclones in companion animals
- Journal of Antimicrobial Chemotherapy, 2019. Klebsiella pneumoniae causing urinary tract infections in companion animals and humans: population structure, antimicrobial resistance and virulence genes