The European Commission has published Guidelines aimed to prevent the overuse and misuse of antibiotics by sharing best-practices in Member States. These guidelines are one of the key deliverables in the EU action plan on AMR. They provide Member States’ authorities, farmers and veterinarians with practical examples of what is being done in other EU countries to promote the prudent use of antimicrobials in veterinary medicine. Such measures can contribute to the control of AMR also in human medicine.