MODERN is an international collaborative project investigating the reservoirs and transmission of Enterobacteriaceae producing extended-spectrum β-lactamases, a group of antibiotic-resistant bacteria that has spread worldwide recently.
Completed project
The study is centered in transmission in non-hospital environment such as households and nursing homes, and include food products, environmental reservoirs and wastewater. Advanced epidemiological methods and whole genome sequencing are being used to identify the rate and risk factors for transmission of these bacteria among residents in these environments in order to produce the information needed to build mathematical models explaining their spread, which will allow to estimate the impact of potential control measures.
Very exhaustive and state-of-the-art studies have been carried out to see the characteristics of these bacteria and their way of transmission, which is different in different species. Knowing this, and adding all the demographic characteristics and risk factors collected from each participant, using advanced mathematical methodology, a model is developed that allows predicting transmission. The ultimate goal is to be able to act at critical points in order to end the problem of antibiotic resistance.
Project partners
- Jesús Rodríguez-Baño, Hospital Universitario Virgen Macarena, Spain (Coordinator)
- Evelina Tacconelli, University Hospital Tübingen, Germany
- Stephan Harbarth, University of Geneva, Switzerland
- Jan Kluytmans, University Medical Center Utrecht, Netherlands
- Didier Hocquet, University Hospital, France
- Ben Cooper, University of Oxford, United Kingdom
Project resources
Presentation of the project by coordinator Jesús Rodríguez-Baño: Presentation video MODERN project, February 2022
Publications
- The Journal of Hospital Infection, 2019. Vagino-rectal colonization and maternal–neonatal transmission of Enterobacteriaceae producing extended-spectrum β-lactamases or carbapenemases: a cross-sectional study
- Antimicrobial Resistance & Infection Control, 2018. Intestinal colonization due to Escherichia coli ST131: risk factors and prevalence
- Antimicrobial Resistance & Infection Control, 2018. Intestinal colonization due to Escherichia coli ST131: risk factors and prevalence
- International Journal of Antimicrobial Agents, 2018. Incidence and Risk Factors for Acquisition of Extended-Spectrum β-Lactamase-Producing Enterobacteriaceae in Newborns in Seville, Spain: A Prospective Cohort Study
