Joint Programming Initiative on Antimicrobial Resistance
 

 

Second transnational call for research projects within the Joint Programming initiative on Antimicrobial Resistance

2015

The JPI AMR is pleased to announce its 2nd joint call for transnational research projects in antimicrobial resistance. This call represents a unique opportunity for Europe and Argentina to overcome antimicrobial resistance. It will open between the 17th of March and 12th of May 2015

The following funding organizations are expected to participate in the call:

  • The Ministry of science, technology and productive innovation (MINCYT), Argentina
  • The National Fund for Scientific Research – French speaking community (FNRS), Belgium
  • The Research Foundation – Flanders (FWO), Belgium
  • The French National Research Agency (ANR), France
  • The Federal Ministry of Education and Research (BMBF) represented by Project Management Jülich (PtJ), Germany
  • The Ministry of Health (MoH), Italy
  • The Research Council of Norway (RCN), Norway
  • The National Centre for Research and Development (NCBR), Poland
  • The Swedish Research Council (SRC), Sweden

Aim of the call

Together, the 9 funding agencies involved in this call expect to support around 7M€ in the following topic: “repurposing of neglected antibiotics and characterising antibiotics or antibiotic and non-antibiotic combinations to overcome bacterial antibiotic resistance.”

The aim of the call is to sustain defense against AMR by reviving Neglected and Disused AntiBiotics (ND-AB), designing combinations of ND-AB and antibiotics and also designing combinations of ND-AB and non-antibiotic in order to reduce occurrence of resistance or overcome established resistance. The objectives of the call are to repurpose ND-AB and/or identify, characterise and understand interaction between ND-AB and other antibiotics or non-antibiotics used already in the medical setting, in order to find combinations avoiding selection for resistance.

The rational must be validated through a mechanistic understanding of synergy and/or demonstration of significant improvement of antibiotic use by exploitation of PK/PD characterisation. The different in vivo validation from one proposal should be comparable and it is highly recommended to perform them in the same laboratory. The in vivo validation should include some PK/PD analysis. It should incorporate:

  • In vitro demonstration of potential activity by testing ND-AB or ND-AB in combinations with other antibiotics or possibly in association with non-antibiotics, to overcome antimicrobial resistance or reduce selection for resistance.
    • Screening combinations and respective dosages of components
    • Sustaining such efficacy by understanding the mechanism involved
  • Strategies to improve PK/PD
    • On earlier generation antibiotics
    • On combination of antibiotics
  • Validation of the approaches
    •  in vivo, exclusively in validated animal models of infection (preferentially pneumonia , pyelonephritis or endocarditis)
    • Validation including endpoints such as overcoming resistance of multiresistant strains and/or reduction in selection for resistance or selection of resistance strains/genes.

It would exclude:

  • Studies on the resistance of Mycobacterium tuberculosis
  • Studies with antibiotics and non-antibiotics not commercially available for a clinically use, new formulation are not eligible
  • Development of new animal model

General conditions for application:

Applicants must adhere to the specific regulations of the national funding organisations.

Each transnational consortium submitting a proposal must involve:

• A minimum of three eligible partners from 3 different countries participating in the call

• A maximum of six partners

• A maximum of two partners of the same country per consortium

Submissions of proposals will be in two steps with the following timetable. In both cases, one joint proposal document (in English) shall be prepared by the project partners of a joint transnational proposal, and must be submitted to the Joint Call Secretariat by the coordinator

17th of February 2015 Pre-announcement of the second joint transnational call
17th of March, 2015 Publication of the second joint transnational call
12th of May, 2015 (17:00, CET) Deadline for pre-proposal submission
End of June, 2015 Communication of the results of the pre-proposal assessment (invitation for full proposal)
25th of August, 2015 (17:00, CET) Deadline for full proposal submission
November 2015 Communication of the funding decisions to the applicants
End of 2015, beginning 2016 Expected projects start (also subject to national procedures)

 

 

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